Evaluation of serum level of uric acid among patients with exacerbation of asthma and patients with controlled asthma

Abstract

Introduction: Evidence of increased serum uric acid (UA) levels during asthma exacerbations is still unclear. High levels of UA may lead to increased inflammation; in this regard, we aimed to investigate the level of UA and associated factors in patients with exacerbation of asthma attacks and those with controlled asthma.

Materials and methods: In this study, demographical and clinical data from 300 patients (150 outpatients and 150 hospitalized patients) with asthma who were referred to Razi Hospital, Rasht, Iran, from August 2018 to March 2019 were collected. Also, the UA and spirometry parameters (FEV1, FEV1/FVC) were assessed for patients. All data were analyzed using SPSS version 21 considering a significant level<0.05.

Results: Among 300 patients with asthma, 158 were male, and 142 were female. A significant association was reported between gender, body mass index (BMI), history of smoking, opium consumption, alcohol consumption, number of asthma attacks, family history of asthma, and history of atopy among hospitalized and outpatients (P<0.05). In addition, there was a significant difference between the level of UA in the two groups at the beginning of treatment (P<0.05). Also, a significant difference between the level of UA in hospitalized patients at the beginning and the end of treatment was observed (P<0.05). In addition, a significant difference between the oxygen saturation level among two groups of outpatients and hospitalized patients at the beginning of treatment was seen (P<0.001).

Conclusion: According to our results, the level of UA might be used as a relative predictive factor in the severity of asthma attacks.