Biological properties and therapeutic effects of apigenin and its evaluation on several types of cancer


  • Roshanak Ale-Esmaiel Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Seyyed Mohammad Taghi Razavi-Toosi Medical Biotechnology Research Center, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran / Department of Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran


Inflammation, Apigenin, Cancer, Cell cycle, Apoptosis


Apigenin is a member of the flavonoid family that has been used in medicine for a long time. Apigenin is one of the compounds that has been used for a long time to treat various disorders and diseases. Apigenin is chemically known as 4',5,7, trihydroxyflavone and belongs to the family of flavones. Apigenin has many pharmacological activities such as anti-inflammatory, anti-viral, anti-bacterial, etc. Various studies have shown that apigenin plays an important role in suppressing diseases such as Parkinson's, Alzheimer's, inflammatory diseases, and different types of cancers. In the present study, various therapeutic properties, biological effects, and the effect of apigenin on different cancers are discussed. Different studies have been conducted on the anti-cancer effect of apigenin. It has been proven that apigenin has inhibitory effects on various cancers including lung, stomach, neuroblastoma, thyroid, liver, skin, and prostate cancer through different signaling pathways. In general, it can be mentioned that the anti-cancer properties of apigenin are due to its effects in various signaling pathways such as angiogenesis, tumor suppressor genes, apoptosis, cell cycle and nuclear factor kappa B (NF-κB), Janus kinase/signal transducer and activator of transcription (JAK/STAT3), phosphoinositide 3-kinase /protein kinase B /mammalian target of rapamycin (PI3K/AKT/mTOR), mitogen-activated protein kinase/ estrogen receptor 2 (MAPK/ER2), Wnt/B-catenin pathways.



How to Cite

Ale-Esmaiel, R., & Razavi-Toosi, S. M. T. (2023). Biological properties and therapeutic effects of apigenin and its evaluation on several types of cancer. Journal of Current Oncology and Medical Sciences, 3(4), 650–662. Retrieved from