Relationship between DNA methylation mechanism and Sonic Hedgehog family (SSH) genes in carcinogenesis and tumorigenesis of gastrointestinal cancers

Authors

  • Sogand Vahidi Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Fatemeh Nejatifar Department of Hematology and Oncology, Razi hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  • Seyedeh Elham Norollahi Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran
  • Ali Akbar Samadani * Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran / Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran

Keywords:

Sonic Hedgehog, Carcinogenesis, Tumorigenesis, Gastrointestinal cancers

Abstract

Gastrointestinal cancers are among the most serious cancers. In addition to environmental factors, genetic and epigenetic factors also play a key role in the development of gastrointestinal cancers. Since many molecular pathways are involved in the development of this type of cancer, the study of the function of molecular mechanisms involved in carcinogenesis and tumorigenesis and their relationship with genes involved in this malignancy in different molecular pathways to identify biomarkers used in early detection it is of great importance. The role of the Sonic Hedgehog signaling pathway in maintaining and controlling stem cell growth and its association with genes involved in gastrointestinal cancers has been reported. In this study, the importance and relationship between the DNA methylation mechanism and genes of the Sonic Hedgehog family in carcinogenesis and tumorigenesis of gastrointestinal cancers will be investigated.

Additional Files

Published

2022-06-30

How to Cite

Vahidi , S. ., Nejatifar , F. ., Norollahi , S. E. ., & Samadani *, A. A. . (2022). Relationship between DNA methylation mechanism and Sonic Hedgehog family (SSH) genes in carcinogenesis and tumorigenesis of gastrointestinal cancers . Journal of Current Oncology and Medical Sciences, 2(2), 225–233. Retrieved from http://submission.journalofcoms.com/index.php/JCOMS/article/view/45

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