Relationship between DNA methylation mechanism and Sonic Hedgehog family (SSH) genes in carcinogenesis and tumorigenesis of gastrointestinal cancers

Abstract

Gastrointestinal cancers are among the most serious cancers. In addition to environmental factors, genetic and epigenetic factors also play a key role in the development of gastrointestinal cancers. Since many molecular pathways are involved in the development of this type of cancer, the study of the function of molecular mechanisms involved in carcinogenesis and tumorigenesis and their relationship with genes involved in this malignancy in different molecular pathways to identify biomarkers used in early detection it is of great importance. The role of the Sonic Hedgehog signaling pathway in maintaining and controlling stem cell growth and its association with genes involved in gastrointestinal cancers has been reported. In this study, the importance and relationship between the DNA methylation mechanism and genes of the Sonic Hedgehog family in carcinogenesis and tumorigenesis of gastrointestinal cancers will be investigated.