Investigating the molecular mechanism of cancer stem cells (CSCs) in treatment of gastrointestinal cancers

Authors

  • Seyedeh Elham Norollahi Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran
  • Sogand Vahidi Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Fatemeh Nejatifar * Department of Hematology and Oncology, Razi hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  • Ali Akbar Samadani * Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran / Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran

Keywords:

Cancer stem cells, Gastrointestinal cancers, Molecular mechanism

Abstract

Cancer stem cells (CSCs) are involved in tumor formation, drug and radiation resistance, invasive growth, metastasis, and tumor progression and are major causes of cancer-related mortality. Gastrointestinal cancers are one of the most common malignancies and causes of cancer death worldwide. Because gastrointestinal cancer stem cells are thought to be resistant to common treatments, new and effective treatments are needed. Cancer stem cells have been reported in colorectal, esophageal, gastric, liver and pancreatic cancers. Given that, understanding the formation of cancer stem cells and identifying control pathways and investigating the molecular mechanism of signaling involved in these cells and their role in cancer treatment leads to the development of diagnostic and therapeutic methods in basic and clinical cancer research. In this study, the functional role and molecular mechanisms of cancer stem cells in the treatment of gastrointestinal cancers are investigated.

Additional Files

Published

2022-06-30

How to Cite

Norollahi , S. E. ., Vahidi, S., Nejatifar *, F. ., & Samadani *, A. A. . (2022). Investigating the molecular mechanism of cancer stem cells (CSCs) in treatment of gastrointestinal cancers. Journal of Current Oncology and Medical Sciences, 2(2), 202–209. Retrieved from http://submission.journalofcoms.com/index.php/JCOMS/article/view/46

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