Variable performance of lncRNA in breast cancer

Sogand Vahidi; Fatemeh  Nejatifar; Mostafa  Khaleghipoor; Habib  Eslami Kenarsari

Authors

Sogand Vahidi Clinical Research Development Unit of Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
Fatemeh Nejatifar Department of Hematology and Oncology, Razi hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Mostafa Khaleghipoor Anesthesia, Neyshabur University of Medical Sciences, Neyshabur, Iran
Habib Eslami Kenarsari Inflammatory Lung Diseases Research Center, Department of Internal Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran

Keywords:

Breast cancer, Long non-coding RNA, Cell proliferation, Molecular mechanisms

Abstract

Introduction: Breast cancer, is one of most frequent cancers across women, is recognized as a diverse and difficult disease that continues to be a serious public health problem. Long non-coding RNAs have already attracted a lot of interest as a result of the advancement of next-generation sequencing methods. Various studies indicate that long non-coding RNAs play an essential part in tumor growth. Even though the biological purpose and molecular processes of long non-coding RNAs are still unknown, modern data has shown that a variety of long non-coding RNAs express inappropriately in malignancies, particularly breast cancer. This review highlighted the most recent research on long non-coding RNAs in breast cancer, with an emphasis on the many molecular functions of regulatory long non-coding RNAs.